
Charu Thakur and Bhairav Prasad
Antiinflammatory Activity of Stem Bark of Rhamnus purpureus
Int.J.Adv.Microbiol.Health.Res.2019; 3(1):21-28
Publisher: IJAMHR, Category: Current Issues
Abstract
This study was facilitated to screen the anti-inflammatory effect of bark of the
Rhamnuspurpureus.Rhamnuspurpureus frequently known as Gaunta . it is deciduous shrub
originatedin the Himalayan range, Himachal Pradesh and Bhutan. In present study the stem
bark of Rhamnuspurpureus was chopped and extracted in ethanol butenol, chloroform and
evaluated for carregenum, cotton pallet induced granulloma in Wister Albino Rats. The
results revealed that cruedethonolic extract showed maximum inhibition in caragenum
induced rat paw edema followed by ethanol, butenol, and chloroform extract. The ethonolic
extract of infective dose 200mg/kg body weight exhibit remarkable anti inflammatory
activity with inhibition of 41.05%, 49.35%, 54.30%, and 54.77%, and butanolic extract
showed significant results viz. 46.01%, 49.80%, 49.17%, 50.28%. and the standard drugs
indomethacin also compared (10mg/ kg) showed inhibition of 50.69%, 51.63%, 50.46%,
51.78% after 1,2,3,and 4 hours of treatment respectively. The result indicates that the
ethonolic extract as well as butonilic extract revealed strong inflammatory activity while
chloroform showed less effective in comparision with indomethicin. The order of inhibition
of carregenum induced rat paw edema was establish to be - indomethecine> ethanol
>butonol>chloroform>. In conclusion to above study it has been seen that the
Rhamnuspurpureus was found to have great anti-inflammatory response and can be
substitute or alternative for synthetic or chemically derived drugs.
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