Prevalence of Inducible Clindamycin Resistance in Clinical Isolates of Coagulase Negative Staphylococci at a Tertiary Care Hospital in Haryana
Publisher: IJAMHR, Category: Current Issues
Coagulase-negative staphylococci (CoNS) are one of the major nosocomial pathogens, having a considerable effect on individual health and wellbeing. Increased resistance in this organism has become threat. This study was done to determine the percentage of Coagulase-negative Staphylococci (CONS) isolates having inducible clindamycin resistance. 150 Coagulase negative Staphylococci isolated from different specimens were subjected to routine antibiotic sensitivity testing by Kirby Bauer disc diffusion method. All isolates were tested for Methicillin resistance by using Cefoxitin 30 μg disc. Inducible clindamycin resistance was detected by ‘D’ test as per CLSI guidelines. Among the 150 CONS isolates, 57(38%) isolates were found to be methicillin-resistant CoNS (MRCoNS) and 93(62%) were methicillin sensitive (MSCoNS). In this study Constitutive MLSB phenotype was most predominant 39 (26%) followed by MS phenotype37 (24.9 %) and Inducible MLSB phenotype 27 (18%) among CONs species. High Incidence of inducible clindamycin resistance among CONS indicates that inducible clindamycin resistance testing (D-test) should be used as a part of routine antibiotic susceptibility so that these isolates may not be missed in routine antibiotic testing by disk diffusion method.
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